Emerging Approaches in Molecular Profiling Affecting Oncology Drug Discovery

Astellas' Drug Discovery Strategy: Focus on Oncology

Based on the goal of delivering innovative and reliable pharmaceutical products to cancer patients for whom no effective treatments exist, Astellas is focusing its efforts on a strategy of precision medicine in its drug discovery which is carried out at three research sites with diversity in their research platforms and research styles.

Oncology drug discovery: planning a turnaround.

We have made remarkable progress in our understanding of the pathophysiology of cancer. This improved understanding has resulted in increasingly effective targeted therapies that are better tolerated than conventional cytotoxic agents and even curative in some patients. Unfortunately, the success rate of drug approval has been limited, and therapeutic improvements have been marginal, with too f...

Computational and Structural Approaches in Drug Discovery

Fragment approaches in structure-based drug discovery

There has been considerable interest recently in what is known as ;fragment-based lead discovery'. The novel feature of the approach is to begin with small low-affinity compounds. The main advantage is that a larger potential chemical diversity can be sampled with fewer compounds, which is particularly important for new target classes. The approach relies on careful design of the fragment libra...

Novel Approaches and Assays in Drug Discovery